{"product_id":"janumet-xr-50-500mg-56-tablets","title":"Janumet XR 50\/500mg 56 Tablets","description":"\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003eJanumet XR 50 \/ 500 mg 56 Tablets\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003eSitagliptin + Metformin\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003eSitagliptin is (DPP-4) inhibitor, the effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar, for that it is used to in diabetes mellitus type2.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003eMetformin is a Biguanide with an anti-hyperglycemic effect that lowers both basal and postprandial glucose and does not stimulate the insulin formation. It acts by reducing the hepatic glucose formation by preventing gluconeogenesis and glycogenolysis. It also increases sensitivity of the insulin in the muscles thus improving peripheral glucose utilization.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Type 2 diabetes mellitus.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003ePoints of interest:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• To reduce stomach upset, take this tablet with food or just after food.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Tell your doctor if you experience nausea, vomiting, loss of appetite or cramps.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Metformin has slow onset of action, it may take up to 2 weeks to establish control.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003eHow to use:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003eAs per as direction of doctor.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003e\u003cbr\u003eActive Ingredients:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003eSitagliptin , Metformin.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003e\u003cbr\u003eSide effects:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Malabsorption of vitamin B12.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Nausea.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Vomiting.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Anorexia.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Diarrhea.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Headache.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Joint pain.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003eCautions:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Metformin is excreted by kidneys, serum creatinine levels should be determined before initiating treatment and regularly thereafter.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Decreased renal function in elderly is frequent and asymptomatic.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• As the IV administration of iodinated contrast material in radiologic studies can lead to renal failure, metformin should be discontinued prior to, or at the time of test and not be reinstituted until 48 hours afterwards.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e•Containdicated in patients with heart failure.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e•Contraindicated in patients with pancreatitis.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003eInteractions:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• ACE inhibitors: the hypoglycemic effect of metformin is possibly enhanced when given with ACE inhibitors\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Beta-blockers: warning signs of hypoglycemia (such as tremor) with metformin may be masked when given with beta-blockers.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Cimetidine: the excretion of metformin is reduced by cimetidine.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Furosemide: may reduce the effectiveness of sitagliptin and other diabetic medications.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e• Levothyroxine: may reduce the effectiveness of sitagliptin.\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003e\u003cbr\u003eQuantity:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e56 Tablets\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003e\u003cstrong\u003e\u003cbr\u003eHow to store:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch2\u003e\u003cspan style=\"font-size: 12pt;\"\u003eKeep at room temperature.\u003c\/span\u003e\u003c\/h2\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":43833258082394,"sku":"1211984","price":14.99,"currency_code":"KWD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0754\/8731\/4010\/files\/62a87b5a0959d18ec29934b1_janumet-xr-50500mg-56-tablets.png?v=1786523903","url":"https:\/\/alnowairpharmacy.com.kw\/products\/janumet-xr-50-500mg-56-tablets","provider":"Alnuwair","version":"1.0","type":"link"}